GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs1552244 | 1 | rs6793396 | chr3:10110927 | VHL | chr3:10183319-10193744:+ | -0.2 | -4.51 | 8.09E-6 | Alzheimer's disease |
| THCA | cis | rs10935120 | 1 | rs6793487 | chr3:134299426 | ANAPC13 | chr3:134196547-134204865:- | -0.36 | -11.4 | 8.25E-27 | Height |
| THCA | cis | rs10935120 | 1 | rs6793487 | chr3:134299426 | CEP63 | chr3:134204575-134293852:+ | -0.3 | -6.62 | 9.81E-11 | Height |
| THCA | cis | rs73201462 | 1 | rs67940364 | chr3:127833353 | EEFSEC | chr3:127872313-128127488:+ | -0.25 | -4.42 | 1.23E-5 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio |
| THCA | cis | rs73201462 | 1 | rs6794591 | chr3:128031219 | EEFSEC | chr3:127872313-128127488:+ | -0.19 | -3.44 | 0.000634 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio |
| THCA | cis | rs9790314 | 1 | rs6794601 | chr3:160946769 | NMD3 | chr3:160939099-160971319:+ | -0.1 | -3.54 | 0.000445 | Morning vs. evening chronotype |
| THCA | cis | rs9876781 | 1 | rs6794875 | chr3:48455626 | ATRIP | chr3:48488141-48507708:+ | 0.2 | 4.31 | 1.95E-5 | Longevity |
| THCA | cis | rs9876781 | 1 | rs6794875 | chr3:48455626 | TREX1 | chr3:48501186-48509043:+ | -0.25 | -5.75 | 1.58E-8 | Longevity |
| THCA | cis | rs679515 | 1 | rs679515 | chr1:207750568 | CR1 | chr1:207669473-207815109:+ | 0.16 | 3.36 | 0.000828 | Alzheimer's disease in APOE e4+ carriers |
| THCA | cis | rs6805251 | 1 | rs6795653 | chr3:119610565 | GSK3B | chr3:119540804-119813264:- | 0.14 | 4.82 | 1.94E-6 | HDL cholesterol |
| THCA | cis | rs573521 | 1 | rs679620 | chr11:102713620 | MMP1 | chr11:102660641-102668966:- | 0.25 | 4.39 | 1.38E-5 | Cerebrospinal fluid levels of Alzheimer's disease-related proteins |
| THCA | cis | rs9815354 | 1 | rs6796210 | chr3:41851718 | ULK4 | chr3:41288091-42003660:- | 1.09 | 21.12 | 2.07E-70 | Diastolic blood pressure |
| THCA | cis | rs9876781 | 1 | rs6796491 | chr3:48430465 | ATRIP | chr3:48488141-48507708:+ | 0.17 | 3.81 | 0.000155 | Longevity |
| THCA | cis | rs9876781 | 1 | rs6796491 | chr3:48430465 | TREX1 | chr3:48501186-48509043:+ | -0.26 | -5.97 | 4.57E-9 | Longevity |
| THCA | cis | rs9815354 | 1 | rs6797165 | chr3:41887777 | ULK4 | chr3:41288091-42003660:- | 1.09 | 20.95 | 1.28E-69 | Diastolic blood pressure |